Warriors professionals Hamish Mitchell and Ed Kalman both feature in the match-day 22 as well as hooker Pat MacArthur.
Dave McCall is in the Heriot's squad to play Nottingham at Goldenacre on Saturday.
Other Warriors could feature in the Gael Force team that will play the Cornish Pirates at the Recreation Ground, Penzance on Sunday.
Competition rules dictate that just two of Ayr’s three overseas players are available for selection, forcing Murray to rest stand-off Frazier Climo, who’s expected to feature against Rotherham at Millbrae the following weekend (Friday 27 November, Millbrae, ko 8.00pm).
Further changes see Dougie Steele come in at full-back while Scotland 7s internationalist, Grant Anderson, moves to centre and Ross Curle steps into the vacant stand-off slot.
15 Dougie Steele
14 A Wilson
13 Grant Anderson
12 Mark Stewart
11 Cammy Taylor
10 Ross Curle
9 Jamie Hunter
1 Gordon Sykes
2 Pat MacArthur
3 Hamish Mitchell
4 Damien Kelly CAPTAIN
5 Scott Sutherland
6 John Crossan
7 Paul Burke
8 Andy Dunlop
REPLACEMENTS
16 Stuart Fenwick
17 Ed Kalman
18 Gordon Reid
19 Scott Nimmo
20 Glen Tippett
21 AJ McFarlane
22 Steven Manning