Last season's Premiership winners Ayr travel to Meggetland to face Boroughmuir with Pat MacArthur, Robbie Smith and Stafford McDowall in the starting XV.
Glasgow Hawks face newly-promoted side Marr at Scotstoun with George Horne, Patrick Kelly, Robert Beattie, Sam Yawayawa and Grant Stewart all starting.
Kaleem Barreto starts at scrum-half for the Premiership new boys.
Stirling County travel to Edinburgh to take on Heriot's with Chris Fusaro and Lewis Wynne starting.