The Scotland international ruptured his knee ligaments during a Champions Cup pool-stage match away to Bayonne on 15 December last year but has not featured for his club since recovering.
Head coach Franco Smith has now released Smith to make his comeback for the Scotland side when they play Italy at Edinburgh's Hive Stadium on Saturday.
The match marks the first 'Emerging Scotland' fixture and forms part of the national academy pilot programme launched in September.
Smith travelled to the 2023 World Cup with Scotland as head coach Gregor Townsend's second-choice full-back, and he is now focused on working his way back into first-team contention before the Six Nations.