Prop Ricky Davies will make his first Scarlets start, allowing veteran tight-head John Davies to sit out his first game of the season.
Scrum-half Liam Davies will also get a debut in the absence of Dwayne Peel, who had ankle surgery this week.
But wing Garan Evans does not return from hand injury, Dafydd James moving to wing with Matthew Watkins in at centre, Tal Selley dropping out.
Gareth Bowen is in for Mike Hercus as the fly-halves continue their battle.
Summer recruits Hottie Louw and Inoke Afeaki will start together in the second row for the first time.
Bowen will be out to impress after training with the Wales squad this week.
"It's good to know that people are watching," said Bowen.
The fly-half's form has improved remarkably this season, and he will be out to erase the memory of a nightmare performance in the Scarlets' 30-57 loss to Glasgow at Stradey last April.
That completed the double for the Scots over the Llanelli outfit in last year's league campaign, following a 40-29 win in Glasgow.
"Glasgow work as a team, they always stay in the game and they like to run it from anywhere as they showed at Stradey last April," said Scarlets captain Simon Easterby.
"But we are better as a team this year, players are back from injury and in form, and the squad as a whole is stronger.
"The Powergen Cup went well, but our Celtic League performances have been poor so far.
"We owe the crowd one, and there'll be no need for motivation ahead of the Heineken Cup."
Scarlets: L Byrne; D James, M Watkins, R King, M Jones; G Bowen, L Davies; I Thomas, A Gravelle, R Davies, I Afeaki, H Louw, J Mills, A Popham, S Easterby (capt).
Replacements: D Williams, M Rees, C Wyatt, A Jones, C Stuart-Smith, M Hercus, G Evans.
Referee: Donal Courtney (Ireland)