In the backs there is a double change at half-back with Chris Cusiter and Dan Parks paired. Andrew Henderson is in his familiar inside centre berth and Chris Paterson is restored to the starting line-up at full-back. Wings Sean Lamont and Simon Webster swap beats.
Simon Taylor replaces the injured Jason White in the only change in the pack.
On the bench Ross Ford and Alastair Kellock are introduced to the personnel who were on duty in the 48-6 win against Romania.
Hadden said: "It's obviously a blow to lose Jason but to be able to call upon Simon means that we have proven quality and experience in our back-row.
"I know Simon well and I also trust the guidance of our medical team headed by Dr James Robson. I would never gamble on a player's fitness."
Hadden noted that the changes in the backs reflected his desire to cast his eye over players who have traditionally served their country well.
He added: "We have scored 114 points in our last two appearances at Murrayfield. Wales had to play out of their skins to beat the Pacific Islanders last weekend. I think both sides are well set to produce an absolute cracker on Saturday."
Scotland team to play the Pacific Islanders at Murrayfield on Saturday 18 November (kick-off 2.30pm)
15 Chris Paterson (Edinburgh Rugby) CAPTAIN
14 Simon Webster (Edinburgh Rugby)
13 Marcus Di Rollo (Edinburgh Rugby)
12 Andrew Henderson (Glasgow Warriors)
11 Sean Lamont (Northampton Saints)
10 Dan Parks (Glasgow Warriors)
9 Chris Cusiter (Border Reivers)*
1 Gavin Kerr (Border Reivers)
2 Dougie Hall (Edinburgh Rugby)
3 Euan Murray (Glasgow Warriors)*
4 Nathan Hines (Perpignan)
5 Scott Murray (Edinburgh Rugby)
6 Simon Taylor (Edinburgh Rugby)
8 Johnnie Beattie (Glasgow Warriors)*
7 Kelly Brown (Border Reivers)*
Substitutes
16 Ross Ford (Border Reivers)*
17 Allan Jacobsen (Edinburgh Rugby)
18 Alastair Kellock (Glasgow Warriors)*
19 Dave Callam (Edinburgh Rugby)*
20 Mike Blair (Edinburgh Rugby)*
21 Phil Godman (Edinburgh Rugby)
22 Hugo Southwell (Edinburgh Rugby)
* = Member of Scottish Institute of Sport
Referee: Bryce Lawrence (New Zealand). Touch-judges: Alan Lewis and George Clancy (both Ireland). TMO: Hugh Watkins (Wales)
Not available due to injury: Rob Dewey (Edinburgh Rugby) and Jason White (Sale Sharks)