The uncapped full-back is joined on the bench by fellow-Warriors Alastair Kellock, Dougie Hall, Ruaridh Jackson, John Barclay and Henry Pyrgos.
Stuart Hogg, Ryan Grant and Sean Lamont feature in the starting XV.
Scotland head coach Andy Robinson said: “Dougie Hall has had a good season for Glasgow and I know that John Barclay has been one of our most consistent and reliable back-row forwards since he made his debut five years ago.
“Peter Murchie is another who has had a fine start to the season with Glasgow and his desire to dominate in aerial combat has been a factor in selection.”
Scotland
15 Stuart Hogg (Glasgow Warriors)
14 Sean Lamont (Glasgow Warriors)
13 Nick De Luca (Edinburgh Rugby)
12 Matt Scott (Edinburgh Rugby)
11 Tim Visser (Edinburgh Rugby)
10 Greig Laidlaw (Edinburgh Rugby)
9 Mike Blair (Brive)
1 Ryan Grant (Glasgow Warriors)
2 Ross Ford (Edinburgh Rugby)
3 Euan Murray (Agen)
4 Richie Gray (Sale Sharks)
5 Jim Hamilton (Gloucester)
6 Alasdair Strokosch (Perpignan)
7 Kelly Brown (Saracens) Captain
8 David Denton (Edinburgh Rugby)
Substitutes
16 Dougie Hall (Glasgow Warriors)
17 Kyle Traynor (Bristol Rugby)
18 Geoff Cross (Edinburgh Rugby)
19 Alastair Kellock (Glasgow Warriors)
20 John Barclay (Glasgow Warriors)
21 Henry Pyrgos (Glasgow Warriors)
22 Ruaridh Jackson (Glasgow Warriors)
23 Peter Murchie (Glasgow Warriors)