Alex Dunbar will make his 100th appearances for the Warriors as new head coach Dave Rennie names his first competitive Warriors squad.
Alex has scored 12 tries in his eight years with Glasgow and will be joined by Sam Johnson in the middle of the park at the Sportsground.
Ruaridh Jackson begins his second stint at the Warriors in the number 15 jersey, adding to his 113 Glasgow appearances following three years playing in England.
On the wing, Lelia Masaga will make his competitive debut, the former All Black having impressed against the Dragons in pre-season while Lee Jones completes the back three.
George Turner is another player representing the club for the first time, packing down with Jamie Bhatti and Zander Fagerson either side of him.
Tim Swinson combines with Scott Cummings in the second-row, scrumming down in front of Matt Smith, Adam Ashe and newly appointed club captain Ryan Wilson.
Oli Kebble and Adam Hastings will be both looking to make their debuts off the bench and BT Sport Scottish Rugby Academy players Adam Nicol and Matt Fagerson are also named amongst the replacements.
Glasgow Warriors Assistant Coach, Jonathan Humphreys, said: "There are different people at Glasgow, there are different coaches at Connacht and with pre-season games you can't really tell how they're going to go.
"Ruaridh (Jackson) played really well against the Dragons. We were all really impressed with him. It's great to have him back - he's played over 100 times for the club and it's as if he's never been away.
"Reaching 100 caps will mean a lot to Alex Dunbar, he says it's been a long time coming! It's a special group, those 100 cap guys, so it'll be a proud moment for him tomorrow night."
14 Lelia Masaga
13 Alex Dunbar
12 Sam Johnson
11 Lee Jones
10 Peter Horne
9 Ali Price
1 Jamie Bhatti
2 George Turner
3 Zander Fagerson
4 Tim Swinson
5 Scott Cummings
6 Ryan Wilson (Captain)
7 Matt Smith
8 Adam Ashe
Substitutes
16 James Malcolm
17 Oli Kebble
18 Adam Nicol
19 Greg Peterson
20 Matt Fagerson
21 Henry Pyrgos
22 Adam Hastings
23 Leonardo Sarto