Zander Fagerson returns to the front row having missed out on last weekend's opening win over England at Twickenham, with fellow tighthead prop WP Nel moving to the replacements' bench.
54-cap Fagerson will form a front row also containing tighthead prop Pierre Schoeman and hooker George Turner.
Vice-captain Grant Gilchrist again partners Richie Gray in the second row, with Matt Fagerson packing down at the base of the scrum, flanked by captain Jamie Ritchie and Luke Crosbie.
In the backs, winger Duhan van der Merwe is joined in the back three by Kyle Steyn and Stuart Hogg, who continues at full-back.
Sione Tuipulotu and Huw Jones continue their centre partnership, with Finn Russell and Ben White resuming their half-back roles.
Aside from Nel, the replacements also remain unchanged, with Fraser Brown, Jamie Bhatti, Jonny Gray and Jack Dempsey in line to bolster the forwards when required and George Horne, Blair Kinghorn and Chris Harris likewise for the back division.
Scotland
15 Stuart Hogg (Exeter Chiefs) 97 caps
14 Kyle Steyn (Glasgow Warriors) 6 caps
13 Huw Jones (Glasgow Warriors) 32 caps
12 Sione Tuipulotu (Glasgow Warriors) 12 caps
11 Duhan van der Merwe (Edinburgh Rugby) 24 caps
10 Finn Russell (Racing 92) 66 caps
9 Ben White (London Irish) 10 caps
1 Pierre Schoeman (Edinburgh Rugby) 17 caps
2 George Turner (Glasgow Warriors) 31 caps
3 Zander Fagerson (Glasgow Warriors) 54 caps
4 Richie Gray (Glasgow Warriors) 70 caps
5 Grant Gilchrist (Edinburgh Rugby) - Vice-Captain - 60 caps
6 Jamie Ritchie (Edinburgh Rugby) - Captain - 37 caps
7 Luke Crosbie (Edinburgh Rugby) 3 caps
8 Matt Fagerson (Glasgow Warriors) 29 caps
Substitutes
16 Fraser Brown (Glasgow Warriors) 58 caps
17 Jamie Bhatti (Glasgow Warriors) 26 caps
18 WP Nel (Edinburgh Rugby) 51 caps
19 Jonny Gray (Exeter Chiefs) 73 caps
20 Jack Dempsey (Glasgow Warriors) 5 caps
21 George Horne (Glasgow Warriors) 19 caps
22 Blair Kinghorn (Edinburgh Rugby) 39 caps
23 Chris Harris (Gloucester Rugby) 40 caps