Rory Lamont is on the wing with Graeme Morrison continuing his return from injury with a start at centre, while Warriors hooker Fergus Thomson is joined by team-mate Moray Low in the front row.
John Beattie of Glasgow Warriors starts at No. 8 with team-mate Donnie Macfadyen at flanker.
Colin Gregor and John Barclay are among Scotland's replacements.
Scotland A team to play Italy A at McDiarmid Park on Friday 23 February, ko 7.30pm, is:
15 Robbie Kydd (Northampton Saints)
14 Simon Danielli (Border Reivers)
13 Graeme Morrison (Glasgow Warriors)
12 Ben MacDougall (Border Reivers)
11 Rory Lamont (Glasgow Warriors)
10 Gordon Ross (CAPTAIN, Castres Olympique)
9 Rob Chrystie (Border Reivers)
1 Ryan Grant (Border Reivers)**
2 Fergus Thomson (Glasgow Warriors)
3 Moray Low (Glasgow Warriors)**
4 Andy Hall (Newport Gwent Dragons)
5 Scott MacLeod (Llanelli Scarlets)
6 Ali Strokosch (Edinburgh Rugby)
7 Donnie Macfadyen (Glasgow Warriors)
8 John Beattie (Glasgow Warriors)
Substitutes:
16 A Kelly (Edinburgh Rugby)
17 Ed Kalman (Border Reivers)
18 Mark Rennie (Bourgoin)
19 John Barclay (Glasgow Warriors)
20 Colin Gregor (Glasgow Warriors)
21 Calum MacRae (Border Reivers)
22 Ben Cairns (Edinburgh Rugby)
** = National Academy player