Glasgow's Kelly Brown is promoted from the bench and will start instead of Dave Callam at No 8.
Chris Paterson returns at full-back for the injured Rory Lamont. Paterson will thus become Scotland' most-capped back surpassing the 82 caps of his fellow product of the Gala club, Gregor Townsend.
Replacing Paterson and Brown among the substitutes are Graeme Morrison, the 25-year-old Glasgow Warriors centre, who won the last of his six caps four years ago but who was in try-scoring form for the Scotland A team in their win in Italy at the weekend; and Allister Hogg, the Edinburgh back-row forward and captain.
Scotland coach Frank Hadden said: "We believed last week we could win in Cardiff and that still remains the case. Obviously we'e had a dent to our confidence but the squad are now doubly determined to travel to Wales and battle for everything we can get to win on Saturday."
Scotland
15 Chris Paterson (Gloucester)
14 Nikki Walker (Ospreys)
13 Nick De Luca (Edinburgh)
12 Andrew Henderson (Glasgow Warriors)
11 Simon Webster (Edinburgh)
10 Dan Parks (Glasgow Warriors)
9 Mike Blair (Edinburgh)*
1 Allan Jacobsen (Edinburgh)
2 Ross Ford (Edinburgh)*
3 Euan Murray (Northampton Saints)
4 Nathan Hines (Perpignan)
5 Jim Hamilton (Leicester Tigers)
6 Jason White (Sale Sharks) CAPTAIN
8 Kelly Brown (Glasgow Warriors)*
7 John Barclay (Glasgow Warriors)*
Substitutes
16 Fergus Thomson (Glasgow Warriors)*
17 Gavin Kerr (Edinburgh)
18 Scott MacLeod (Llanelli Scarlets)
19 Allister Hogg (Edinburgh)*
20 Chris Cusiter (Perpignan)*
21 Graeme Morrison (Glasgow Warriors)
22 Hugo Southwell (Edinburgh)