Colin Shaw and Hefin O'Hare start on the wings in place of Alex Dunbar and DTH van der Merwe Frederico Aramburu will start in place of Max Evans who is out for one week with a slight calf strain.
In the pack Richie Vernon replaces John Barclay who is rested while Ryan Wilson will start at No 8 instead of John Beattie who is ineligible.
Glasgow coach Sean Lineen said: “In the first game away against Wasps we didn’t do ourselves justice, especially in defence. They have half a dozen British Lions in their team so we’ll need to defend well and get the crowd behind us – every team wants to win their home games and our recent loss to Toulouse at Firhill wasn’t acceptable.
“Obviously physicality of this match is going to be huge. They make you work for every metre and their set-piece is exceptional, with a lot of experienced players, so we’re going to have to go into the game with a lot of energy and accuracy, make it difficult for them to defend and get momentum in attack.
“The gain line is going to be a real battle.”
14 Colin Shaw
13 Federico Aramburu
12 Peter Murchie
11 Hefin O'Hare
10 Ruaridh Jackson
9 Colin Gregor
1 Ryan Grant
2 Dougie Hall
3 Moray Low
4 Richie Gray
5 Alastair Kellock CAPTAIN
6 Robert Harley
7 Richie Vernon
8 Ryan Wilson
Substitites
16 Pat MacArthur
17 Kevin Tkachuk
18 Jon Welsh
19 Aly Muldowney
20 Chris Fusaro
21 Henry Pyrgos
22 Peter Horne
23 David McCall
Wasps
15 Mark Van Gisbergen
14 Tom Varndell
13 Ben Jacobs CAPTAIN
12 Riki Flutey
11 David Lemi
10 Dave Walder
9 Joe Simpson
1 Tim Payne
2 Tom Lindsay
3 Zak Taulafo
4 Simon Shaw
5 James Cannon
6 Joe Worsley
7 Serge Betsen
8 Andy Powell
Substitutes
16 Michael Mayhew
17 Charlie Beech
18 Ben Broster
19 Marty Veale
20 Richard Birkett
21 Nic Berry
22 Dominic Waldouck
23 Richard Haughton