Peter Horne moves from inside centre to fly-half, with Ruaridh Jackson dropping to the bench.
Alex Dunbar comes in for Horne, with Stuart Hogg, Sean Maitland, Niko Matawalu, Josh Strauss, Al Kellock and Ryan Grant also back in the starting XV.
Gregor Townsend said: “Leinster have set the benchmark in European rugby for the last three or four seasons and we are under no illusions as to the size of the challenge that awaits us in Dublin.
“Winning in Galway has created vital momentum for us after our home victory against the Ospreys. It was also important that we were able to deliver a quality performance away from home against tough opponents. We return to Ireland this weekend with renewed confidence and determination.
We narrowly lost to Leinster in March but we were pleased with a number of aspects of our game that night. We’ve improved since then and we’re really looking forward to another opportunity to play at the RDS.”
We narrowly lost to Leinster in March but we were pleased with a number of aspects of our game that night. We’ve improved since then and we’re really looking forward to another opportunity to play at the RDS.”
Hogg replaces Peter Murchie at full-back, Sean Maitland comes in for Tommy Seymour on the right wing, with the clubs all-time leading try scorer DTH van der Merwe keeping his place on the left flank.
Dunbar will partner Sean Lamont at centre, with Horne starting at fly-half.
After signing a new deal this week to keep him at Scotstoun until 2015, Niko Matawalu starts ahead of Henry Pyrgos at scrum-half.
John Welsh keeps his place at tight head, with Ryan Grant coming in at loose head in place of Moray Low and Pat MacArthur continuing at hooker.
Captain Al Kellock is back in the side after missing the game against Connacht and he will partner Tim Swinson in the second-row.
Josh Strauss comes in for Rob Harley at blind-side, with Barclay starting at open-side and Ryan Wilson at number eight.
After signing a one-year deal this week, hooker Fraser Brown starts on the bench for the Warriors, with Dougie Hall out injured. Glasgow also have Ed Kalman, Moray Low, Tom Ryder, Rob Harley, Henry Pyrgos, Ruaridh Jackson and Mark Bennett in reserve.
15 Stuart Hogg
14 Sean Maitland
13 Sean Lamont
12 Alex Dunbar
11 DTH van der Merwe
10 Peter Horne
9 Nikola Matawalu
1 Ryan Grant
2 Pat MacArthur
3 Jon Welsh
4 Tim Swinson
5 Alastair Kellock
6 Josh Strauss
7 John Barclay
8 Ryan Wilson
Substitutes
16 Fraser Brown
17 Moray Low
18 Ed Kalman
19 Tom Ryder
20 Robert Harley
21 Henry Pyrgos
22 Ruaridh Jackson
23 Mark Bennett