The Scotland international open-side makes his first appearance of the season at Scotstoun on Friday night, as third play fourth.
Josh Strauss, released from Scotland camp, joins Chris in the back-row and will captain the side from number 8 with Lewis Wynne starting at blind-side.
Tim Swinson is another player made available to the Warriors this weekend and he joins Brian Alainu'uese in the second-row.
They will scrum down behind Gordon Reid fresh from Scotland duty as well as Corey Flynn and D'arcy Rae, with the tight-head prop making his first start of the season.
Grayson Hart also makes his first start of the campaign, pairing up with Rory Clegg in the half backs while in the centres Sam Johnson and Nick Grigg combine.
The back three boast nearly 250 Warriors appearances between them as Lee Jones and Sean Lamont flank full-back Peter Murchie.
There is another injury boost on the bench as Ryan Grant is included in a match day squad for the first time since the opening day of the season.
Stirling County prop Adam Nicol will look to bring his fine BT Premiership form to the PRO12, involved with the Warriors for the first time.
BT Sport Scottish Rugby Academy players George Horne and Patrick Kelly are in line to make their competitive Glasgow debuts, with both having impressed in the side's pre-season victory over Canada 'A'.
Junior Bulumakau also features for the first time this season, rewarded for his fine try-scoring form for Glasgow Hawks.
More than 7,000 tickets have been sold for the match with less than 200 still available and they can be purchased from glasgowwarriors.org.
Glasgow Warriors head coach Gregor Townsend said: "Welcoming Chris Fusaro and Ryan Grant back after injury is a real boost.
"They have both worked very hard to get back to full fitness and their inclusion will lift the side for what is going to be a huge challenge against Ospreys,
"Adam Nicol has played very well for Stirling County this season and has looked very impressive training with us over the past few weeks.
"George Horne and Patrick Kelly have earned their first opportunities to be involved with the squad and we're looking forward to see them take the game to the opposition."
14 Sean Lamont
13 Nick Grigg
12 Sam Johnson
11 Lee Jones
10 Rory Clegg
9 Grayson Hart
1 Gordon Reid
2 Corey Flynn
3 D'arcy Rae
4 Tim Swinson
5 Brian Alainu'uese)
6 Lewis Wynne
7 Chris Fusaro
8 Josh Strauss CAPTAIN
Replacements
16 Pat MacArthur
17 Ryan Grant
18 Adam Nicol
19 Robert McAlpine
20 Langilangi Haupeakui
21 George Horne
22 Patrick Kelly
23 Junior Bulumakau
Not available due to injury: Adam Ashe (hip / foot), Scott Cummings (shoulder), Greg Peterson (shoulder), Henry Pyrgos (knee), Leonardo Sarto (shoulder), Tjiuee Uanivi (shoulder) and Richie Vernon (shoulder).