It'll be both players first appearance of the November international series.
There are five changes to the side which grabbed a last-gasp win over the Pumas at Murrayfield last week.
Cumnock-born Mark takes over from Huw Jones, while in the front row Ross Ford replaces Fraser Brown at hooker.
Lock Richie Gray has recovered from a head injury to take the slot filled by Grant Gilchrist while in the back row Robert Harley and Ryan Wilson come in for Marcus Bradbury and John Barclay.
Head Coach Vern Cotter said: "Our players are excited to be back in Kilmarnock and having the west country supporting us like they did two years ago will be great.
"The crowd's enthusiasm will be key to getting a good performance against Georgia. The players feed off the energy from the stands, it's one of these tangible things and really does help spur on the guys.
"We've learned a lot from our previous Tests against Australia and Argentina and that's what these games are about - learning what worked and what didn't and making sure we improve with every game.
"Knowledge gained from our one-point loss to Australia and 83rd-minute victory over Argentina will be important in negotiating Saturday's game in the best way possible to get the win we want.
"Georgia are striving to be among the world's best as they knock on the door of the top 10 in the world rankings.
"We are expecting a typical Georgian game. They will be physical up front as they play a forwards-based game, however they are also developing their backs."
Scotland
15 Stuart Hogg (Glasgow Warriors)
14 Sean Maitland (Saracens)
13 Mark Bennett (Glasgow Warriors)
12 Alex Dunbar (Glasgow Warriors)
11 Tommy Seymour (Glasgow Warriors)
10 Finn Russell (Glasgow Warriors)
9 Greig Laidlaw CAPTAIN (Gloucester)
1 Allan Dell (Edinburgh Rugby)
2 Ross Ford (Edinburgh Rugby)
3 Zander Fagerson (Glasgow Warriors)
4 Richie Gray (Toulouse)
5 Jonny Gray (Glasgow Warriors)
6 Robert Harley (Glasgow Warriors)
7 Hamish Watson (Edinburgh Rugby)
8 Ryan Wilson (Glasgow Warriors)
Substitutes
16 Fraser Brown (Glasgow Warriors)
17 Alex Allan (Glasgow Warriors)
18 Moray Low (Exeter Chiefs)
19 Grant Gilchrist (Edinburgh Rugby)
20 John Barclay (Scarlets)
21 Ali Price (Glasgow Warriors)
22 Peter Horne (Glasgow Warriors)
23 Rory Hughes (Glasgow Warriors)
Unavailable through injury: Alasdair Dickinson (hamstring), John Hardie (ankle), Huw Jones (foot), Henry Pyrgos (knee)