Josh Bayliss, Matt Currie, Dylan Richardson and Kyle Steyn all crossed for Scotland in what was ultimately a comfortable win.
Chile provided a tough physical challenge and the Scots took a while to get going.
However, Scotland gradually wore down their hosts and it was pretty much one-way traffic in the second period.
The opening 20 minutes were scrappy before Bayliss forced himself over from close range, while Santiago Videla kicked two penalties for the hosts either side of that score.
Sione Tuipulotu set up Rowe for his first international try - although the pass looked suspiciously forward.
Shortly after that Ben Healy sent Dobie scurrying in at the corner before the interval.
The scrum-half turned winger was celebrating again early in the second half, with some slick passing stretching the home defence.
Then came the biggest cheer of the day from the 25,000 home fans as replacement hooker Diego Escobar crashed through a couple tackles for Chile's only try.
Edinburgh centre Currie spotted a gap and accelerated through it to grab his own first try for Scotland.
A great break from Rowe looked like it would put the full-back in for his hat-trick but he was denied by a fantastic last-gasp tackle.
Richardson was on hand to finish off some powerful play from Steyn, and the Glasgow skipper was not be denied as he sped away from the exhausted home defence in the final minute of regulation time.
Scotland will complete their summer tour against Uruguay next Saturday.