Zander Fagerson starts at tight-head, with only Blair Kinghorn having made more carries for Scotland in the tournament to date.
Rory Darge co-captains the side from the openside flank, the North Berwick product topping the tackle charts for the men in blue so far in the 2025 Guinness Six Nations.
Darge is joined in the back-row by Jack Dempsey, the number eight set to win his 26th cap for Scotland this weekend.
Tom Jordan continues at inside-centre, his break and inside pass having set up Ben White for Scotland's opening try at Allianz Stadium.
Huw Jones lines up outside his club-mate in the midfield, the centre's try at Allianz Stadium having made him Scotland's joint-top try-scorer in the history of the Guinness Six Nations.
Six Warriors await their opportunity amongst the replacements, with Sutherland once again named as the cover at loose-head prop after recovering from the back spasms that caused his late withdrawal a fortnight ago.
Gregor Brown wears the number 19 jersey in a five-three split of forwards and backs on the bench, with Matt Fagerson joining the Aberdonian as the cover in the back-five of the scrum.
George Horne - now just one try behind DTH van der Merwe in the Glasgow Warriors all-time scoring charts - comes into the matchday 23 to join Stafford McDowall and Kyle Rowe on the bench
Scotland
15 Blair Kinghorn - Toulouse (58)
14 Darcy Graham - Edinburgh Rugby (44)
13 Huw Jones - Glasgow Warriors (56)
12 Tom Jordan - Glasgow Warriors (6)
11 Duhan van der Merwe - Edinburgh Rugby (47)
10 Finn Russell - Co-Captain - Bath Rugby (85)
9 Ben White - Toulon (27)
1 Pierre Schoeman - Edinburgh Rugby (40)
2 Dave Cherry - Edinburgh Rugby (14)
3 Zander Fagerson - Glasgow Warriors (73)
4 Jonny Gray - Bordeaux Begles (80)
5 Grant Gilchrist - Edinburgh Rugby (78)
6 Jamie Ritchie - Edinburgh Rugby (57)
7 Rory Darge - Co-Captain - Glasgow Warriors (28)
8 Jack Dempsey - Glasgow Warriors (25)
Substitutes
16 Ewan Ashman - Edinburgh Rugby (25)
17 Rory Sutherland - Glasgow Warriors (39)
18 Will Hurd - Leicester Tigers (7)
19 Gregor Brown - Glasgow Warriors (7)
20 Matt Fagerson - Glasgow Warriors (53)
21 George Horne - Glasgow Warriors (35)
22 Stafford McDowall - Glasgow Warriors (11)
23 Kyle Rowe - Glasgow Warriors (11)