Cammy Mather has failed to get over the chest injury that ruled him out of the final Six Nations match against Ireland while his fellow flanker Donnie Macfadyen is suspended because he has picked up three yellow cards.
Paul Dearlove comes in to the backrow after recovering from an ankle injury.
Hugh said: "Obviously, we would have liked to have Cammy and Donnie available for this match. But we have a good replacement in Paul."
Glasgow are four points ahead of the Borders going into tonight's home Celtic League match with the Celtic Warriors and need to stay ahead to secure a Heineken Cup spot for next season.