Kyle Rowe lines up on the wing for his first appearance of the championship and is joined in the back-line by Tom Jordan and Huw Jones at centre.
Up front, Zander Fagerson continues at tighthead and will win his 73rd cap for his country on Saturday evening.
Rory Darge once again co-captains the side from the openside flank while Jack Dempsey starts at number eight.
Five further Warriors are on the bench, with Rory Sutherland and Matt Fagerson rotating to the replacements after starting against Ireland last time out.
Gregor Brown continues amongst a six-two split of forwards and backs selected in the matchday 23, as Jamie Dobie and Stafford McDowall once again cover the back-line for Saturday's encounter.
Scotland
15 Blair Kinghorn - Toulouse (57)
14 Kyle Rowe - Glasgow Warriors (10)
13 Huw Jones - Glasgow Warriors (55)
12 Tom Jordan - Glasgow Warriors (5)
11 Duhan van der Merwe - Edinburgh Rugby (46)
10 Finn Russell - Co-Captain - Bath Rugby (84)
9 Ben White - Toulon (26)
1 Pierre Schoeman - Edinburgh Rugby (39)
2 Dave Cherry - Edinburgh Rugby (13)
3 Zander Fagerson - Glasgow Warriors (72)
4 Jonny Gray - Bordeaux Bègles (79)
5 Grant Gilchrist - Edinburgh Rugby (77)
6 Jamie Ritchie - Edinburgh Rugby (56)
7 Rory Darge - Co-Captain - Glasgow Warriors (27)
8 Jack Dempsey - Glasgow Warriors (24)
Substitutes
16 Ewan Ashman - Edinburgh Rugby (24)
17 Rory Sutherland - Glasgow Warriors (39)
18 Will Hurd - Leicester Tigers (6)
19 Sam Skinner - Edinburgh Rugby (36)
20 Gregor Brown - Glasgow Warriors (6)
21 Matt Fagerson - Glasgow Warriors (52)
22 Jamie Dobie - Glasgow Warriors (10)
23 Stafford McDowall - Glasgow Warriors (10)