There are eight changes from the starting XV that played against Leinster on Saturday.
There are six changes in the pack with a completely new second and front row. Mike Phillips will have a fitness test before a decision is taken on who will play at scrum half.
15. Ben Blair
14. Mosese Luveitasau
13. Tom Riley
12. Tom Shanklin
11. Chris Czekaj
10. Nicky Robinson
9. Mike Phillips
8. Xavier Rush (Capt)
7. Martyn Williams
6. Scott Morgan
5. Robert Sidoli
4. Deiniol Jones
3. Toufaao Filise
2. T. Rhys Thomas
1. Gethin Jenkins
Replacements
16. John Yapp
17. Gareth Williams
18. James Goode
19. Mark Lewis
20. Ed Fairhurst
21. Nick Macleod
22. Dai Flannigan